I consider myself lucky. I can, and do, drink a whole bottle of red wine in an evening, about once per week. My wife doesn't drink and I feel it is a crime to put a cork back into a wine bottle. The day after, I feel fine and am sometimes surprised at how mobile I am.
If, however, I eat a large steak with the wine, I am an absolute wreak the following day. But once or twice per year I think it's worth it.