When you become concerned about new/worsening symptoms it is a good idea to check the side effects of any drugs you are taking
Your Drug May Be Your Problem 2007 P.R. Breggin, M. D. Cohen,
3.6.3_21 Drug-induced euphoria sometimes progresses into a psychosis called mania. Probably all antidepressants and stimulants are capable of causing mania, which is characterized by exaggerated or unrealistic feelings of being happy or "high", excitability, insomnia, boundless energy, racing thoughts, grandiose schemes, and feelings of extreme self-importance and omnipotence.
Irritability insensitivity to others, paranoia, and aggression often go along with being manic. During mania, a person can become "physically assaultive or suicidal"
4.11 Medications Used to Treat Drug- Induced Abnormal Movements
This category comprises Symmetrel (amantadine), Sinemet (carbidopalevodopa), Cogentin (benztropine), Akineton (biperiden), Kemadrin (procyclidine), Artane (trihexyphenidyl), and Parsidol (ethopropazine).
4.11_4 The use of these drugs is hazardous in psychiatry because they can mimic symptoms of severe psychiatric disorders, including toxic psychosis, delirium, confusion, excitement, euphoria or giddiness, hallucinations and delusions, insomnia, paranoia, agitation, depression, apathy or listlessness, and bizarre behavior.
They can also cause more subtle interference with memory and thinking processes. Although no studies of this phenomenon have been conducted, we agree with other clinicians who believe that these drugs may cause irreversible mental deterioration when used over the long term.
4.11_5 Neuroleptic malignant syndrome has been reported in connection with Symmetrel and Sinemet. Because both of these drugs bring about their impact by stimulating dopamine, they can also cause twitches, spasms, and other involuntary movements (dyskinesias).
Symmetrel (Amantadine) Professional Information SIDE EFFECTS include:
Insomnia, depression, irritability, hallucinations, Agitation, euphoria, thinking abnormally, amnesia,
suicidal attempt, suicide, and suicidal ideation , delusions, aggressive behavior, paranoid reaction,
LEVODOPA - Psychiatric symptoms include agitation, anxiety, elation and insomnia or some times drowsiness and depression. More severe effects include aggression, paranoid delusions, hallucinations, suicidal behaviour and unmasking of dementia.
SUICIDAL BEHAVIOR INDUCED BY PRAMIPEXOLE DIHYDROCHLORIDE: CASE REPORT Authors: Sant’Angelo R.P., Ambrosini F., Pacetti M. Mental Health Department, Az. Ausl Romagna
With the progressive increase of dopamine agonist doses, hypomanic episodes, psychomotor agitation, irritability, intolerance to frustration or euphoria can be precipitated.
As expected, when an abnormal dopaminergic overstimulation happens may appear thought alterations, delusions, hallucinations and aggression. Increased aggression and inward-directed aggression were associated with hyperactivity in the dopaminergic system in many species.
Mirapex (Pramipexole) Side Effects & Adverse Reactions
‘A.’ Aug.29, 2018, I too have been on Mirapex for 8 years, and have suffered from RLS for that time. … have developed a gambling problem, which I never had before. My personality has became more aggressive…
‘B.’ Dec. 26, 2017, I was started on mirapex about 8 years ago for severe restless leg syndrome… [RELATIONSHIP] Always a gentle, kind person, I was very inappropriate and said some very hurtful things. It was always at night. I’d wake up in the morning a different person, sorry and ashamed…. [my children]. Aggressive paranoid racing thoughts led me to say horrible things. I hurt them so much