hi dotty, you are on the same 4 hourly regime as me except i take 100mg all the time, but if i feel like its starting to wear off i will take it sooner my pd nurse said i could take it 3 hourly if needed so some days i take 100mg at 7am and at 10am instead of 11am then i go back to the 4hrs again works for me, just wondered why you take 50mg at 7pm and not 100mg that might work better than taking the 125, i also take the azilect and mirapexin at 7am, i have learned to read the signs and know when i am starting to knock off i also have the apo-go pen which is brilliant as and when i need it, my pd nurse did increase my stalevo to 125 but like you it did,nt agree with me made me have severe dyskinisias so went back to 100mg and just tweak it as and when good luck hope you can get a happy medium with the meds.sue.