Absolutely everything you wanted to know about neuroprotection and mor


#1

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3221408/

my summary:

Ŏ Ŏ Ŏ = contender 

Ŏ Ŏ = interesting

Ŏ = ho hum

X = oops

XX = oh dear

Contender          Comments          Turnips

Caffeine               Estrogen negates effect               Ŏ Ŏ

nicotine                                Ŏ Ŏ

Urate    Males mainly, gout?       Ŏ Ŏ Ŏ

Vit E                       Ŏ

Vit C & E                               Ŏ Ŏ

Vit C                       X

Vit D      High dose            XX

Beta carotene   If you are a mouse          Ŏ

Riboflavin                            Ŏ Ŏ

Q 10                       Ŏ

Creatine               Phase III trials    Ŏ Ŏ Ŏ

DHA                       Ŏ Ŏ

Melatonin                           Ŏ

GSH                       Ŏ

IP6                          Ŏ

Ibuprofin                             Ŏ Ŏ

Aspirin  Possibly negative effect                X

Isradipine            ‘futile’   Ŏ

phenylbutyrate                Ŏ

Ex 4                        Ŏ Ŏ

Rasagiline            Once more a contender                Ŏ Ŏ Ŏ

Minocycline        Phase III               Ŏ Ŏ Ŏ

Minocycline & creatine                  Ŏ Ŏ Ŏ


#2

Tx turnip, a systematic review of a systematic review. Wasn't the NICE guideline on Rasagiline supposed to have been updated to take account of that 2011 trial? Last I looked it still said you shouldn't prescribe MAO-Bs for their neuroprotective effect except as part of a trial. (Didn't stop my neuro who gaily wrote in her notes "prescribing Rasagiline for its neuroprotective effect . . . )

S


#3

thanks Semele. NICE makes a galapagos tortoise look like a road-runner.

Personally, i have ordered a bucket of creosote. ...the chemist gave me a very funny look.


#4

actually its quite embarrassing ordering creatine - everyone assumes the fat, bald 50ish man is attempting to become a buffed up muscle muffin.