Anyone got information on any practical progreess from this study


#1
http://www.ncbi.nlm.nih.gov/pubmed/20206941

Are there any treatments derived from this?

#2
I am glad you found this reference because it very interesting and promising. I could not find any more on this but I have turned up a couple of references about the role of gangliocides (but they are rather heavy going): http://www.landesbioscience.com/journals/autophagy/WeiAUTO5-6.pdf and http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2671277/

I am trying to get hold of the full paper from the author. Maybe Parkinson's UK can help.

Droflet

#3
Here is another relevant recent reference:

Seung T Lim et al., “Exogenous gangliosides increase the release of brain-derived neurotrophic factor,” Neuropharmacology 60, no. 7-8 (June 2011): 1160-1167. http://www.ncbi.nlm.nih.gov/pubmed/20971126

It shows that gangliosides stimulate the release of neurotrophic factors like BDNF which help to grow and repair nerve cells.

#4
Thanks for picking up on this. I found it in the biog of a PWP in the States saying he had been on the trials.

Due to the good outcomes I am surprised that I cant find it being followed up into a practical treatment. Do I just email Parkinsons UK about it? Is that the best route as I can link the references? Thanks

#5
.......and

http://www.parkinsons-information-exchange-network-online.com/archive/216.html

:smile:

#6
I don't know about practical PROGRESS but I did find a pratical USE for it.

I printed it off and used pages 1-15 to light me barby.
16-45 when sellotaped together made a nice tablecloth.
The rest went to make papier mache, which kept young and old alike amused for all of 10 minutes.

top tip - for more solid structures, use chicken wire and cover it with the papier mache.

Apparently I'm spelling papier mache wrong, but google says I'm right. Maybe we pwp's would be better served getting a report about that little conundrum. :question:

#7
it's all in the accent :grin:

Papier-mâché

#8
Hi,
Sorry it took us a bit to get back to you on this. We won't always be able to answer individual research questions on the forum but to get a quick response, you can always write to us at research@parkinsons.org.uk.

We had a look into it but couldn't find any further information on GM1 ganglioside or new trials. The sort answer to your question is: research like this can take time. This was a relatively small, 'open label' (ie no placebo/control group) study.

So, while the results were promising, much larger and more comprehensive studies are required to follow this up. And setting up these kind of studies requires lots of money (many millions) - and this money can take a while to raise. The study was only published last year so it may take some time for further studies to be set up.

We'll update the website when there is more news.

In the meantime,take a look at the lead research news story on the website today. There's some exciting news.

For the first time, researchers in the US have successfully used nerve cells grown from human embryonic stem cells to repair the brain in animal models of Parkinson's: http://www.parkinsons.org.uk/about_us/news/news_items/all_news/stem_cells_into_brain_cells.aspx

#9
Thanks for the update. And also for the extra good news :)