PD and antidepressants and Rasageline (Azilect)
Azilect has been available since 2005. The early drug company literature says not to take SSRI's with Azilect but many people do with no problems. Since that warning the early literature has been updated. Now the information from Teva is this.
The AZILECT® prescribing information contains a warning regarding concomitant use with antidepressants, they are not contraindicated. It's important for patients to know that AZILECT can be prescribed with antidepressants with proper dosing and careful monitoring.
AZILECT is not contraindicated with antidepressants
• The AZILECT prescribing information contains a warning against the use of AZILECT with antidepressants
• There is a difference: a warning is usually a precaution about potential negative effects; a contraindication spells out specific instances in which the drug should not be used
• The AZILECT warning is similar to that of selegiline, another medication in the same class2
• The use of AZILECT and antidepressants is not contraindicated; however, use caution and apply clinical judgment when using AZILECT to treat PD patients who take an antidepressant
A report which i found interesting, hope it is useful.
HONOLULU -- April 15, 2011 -- The use of the monoamine oxidase-B inhibitor
rasagiline appears safe to use in patients with Parkinson’s disease who are
also being treated with antidepressants, researchers said here at the 63rd
Annual Meeting of the American Academy of Neurology (AAN).
“There has been concern that taking rasagiline and some antidepressants could
cause serotonin syndrome,” said Nisha Chhabria, MD, Georgetown University
Hospital, Washington, DC, on April 14.
“However, in our retrospective study we did not see evidence of a major impact
of this phenomenon,” said Dr. Chhabria. “We don’t think physicians or patients have to be concerned about using these drugs together.