When i was first looking into this in 2011,the consensus was,DO NOT take MAOI anti-depressants with Azilect.Even reading through the information leaflets in front of me now.DO NOT is underlined.It took months for me back then,to sort out.A specialist psychopharmacist gave me the okay after a lot of investigation.Mirtazapine was the only one ruled safe.I was having the side effect of complete hair loss on my lower legs with mirtazapine,in the earlier months.This was noted on the reported side effects register at the time,no others had reported this.At first i assumed that the Azilect/Mirtazapine combo was responsible.I was also taking mirapexin(pramipexole)max dose at same time.
The psychopharmacist and my doctor said the options were stop the Azilect for at least 2 weeks and start the Anti-depressants,then resume the Azilect 2 weeks after stopping the Anti-depressants.The only safe-ish option at that time was the Mirtazapine/Azilect combo.They said to me"definitely NO to any other Anti-depressants,and the side effects of lower leg hair loss was a small price to pay for the hopeful improvement of my mood.Since then my meds have been moved from Mrapexin,a DA to Sinemet.Also,the hair on my legs totally returned to normal.Leading me to believe,that the combination of Azilect/mirtazapine/Mirapexin directly caused this,possibly the Mirtazapine/mirapexin in itself.The area is like a minefield.There are so many side effects and possibilites,that to come onhere and advocate any anti-depressant with Azilect is pure folly,given the information still on the leaflets and what i have experienced.
You would think that with the number of pwp suffering with depression,this matter would be more clear cut,with less conflicting information.Maybe things have moved forward in the 2 years i have been taking Mirtazapine.But according to the leaflets in front of me now,the information is the same,seratonin syndrome and the words DO NOT take together boldly underlined.
Don't forget,that we are all different,some people have more of a tolerance than others.Many people can't take Azilect(full stop),so combine this with a medicine that has contra indications is asking for trouble.
I can personally vouch for the Mirtazapine/Azilect,so think you are right goldengirl.I have been told NO OTHER combo is safe.Read the effects of Seratonin sydrome,some of them are so common,that many pwp may think this is just how they are and not realise that they are drug interactions.The prolonged effect of Azilect can't even be properly quantified yet,it really is still an ongoing test.So to err on the side of caution is the best course of action.