Hi,
I tend to be prescribed different brands of co-careldopa for each prescription (every two months) and I do notice that I frequently have an adjustment period to the change which is never a great thing. I have no idea why but there is one brand that really doesn’t work for me (Somex). I’m quite sure that somebody will tell me that the ingredients are exactly the same as in other brands but I always notice a big difference in terms of reduced symptom control with this brand. Luckily, whatever my GP may think about my observations he has been willing to ask the chemist for me not to have this brand.
I personally feel that Sinemet works the best for me but a request for Sinemet only is going to be met with a resounding ‘no’ so eliminating the worst offenders seem to be my best bet.
The problem, of course, is that there are so many other reasons for fluctuations that I can easily be convinced that I’m incorrect 
.
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