So dissapointing results. Am I surprised ? NOT AT ALL !!! This is exactly why I was complaining a few weeks ago. For example, MANF is testing their product on mice that get PD after poisoning. But these test samples are useless. They should test this on mice with misfolded alpha-synuclein. As I already pointed out, there was a study that said neurotrophic factors DO NOT WORK in an environment with misfolded alpha-synuclein !!!
I restate my complaint. Scientific community should also start testing on mice with misfolded alpha-synuclein !!! Valuable money is being thrown in the gutter in this way. It is a real shame that I still see papers about neuroprotective agents in which no alpha-synuclein models are used.