Good afternoon,
Eleven years in I’m finding that Sinemet Plus ir is causing more problems than it’s solving ( 25/100X6 per day plus 1 x 50/200 controlled release at bedtime.
Headaches, one hours on time and cliff edge end of dose followed by complete immobility.
Has anyone found benefits in using controlled release during the day instead of IR.
Thanks 
Hi, @Ed2.
Thank you for sharing - that sounds really frustrating. You won’t be alone in experiencing that kind of wearing off with immediate-release medication.
Some people do try controlled release in the day to smooth things out, but it can work differently for everyone. It might be worth chatting with your Parkinson’s nurse or consultant, as there could be a few options to tweak things.
If it helps to talk it through with someone sooner, you can speak to our specialist nurses via our free helpline: 0808 800 0303 (9am and 6pm Monday to Friday, and 10am and 1pm on Saturdays).
Hopefully others here can share what’s worked for them too 
Parkinson’s UK Moderation Team
use of controlled release in the day,
Parkinson;s can be miserable. I’m typing this at 3.36am cant sleep because of my PD
However It is now 5 and a half hours since o took Half Sinemet CR 100mg x2 and I am still fully ON and experience tells me I will stay ON now up to about 9am. I will take Stalevo 125 and Madospar disperrsible 50mg at 4.00 am and Stalevo 150 and Safinamide 100mg at 6.30am,
But in the daytime i take mainly Stalevo at about 2 3/4 hour intervals yet still experience OFF periods sometimes lasting an hour or so in the mornings and afternoon , I too have wondered .about using Sinemet CR during the day but never discussed it with mu nurse or consultant
To be honest I think the problems arise when i get food in my stomach. That really messes with my PD control. A few weeks ago i had to be nil by mouth for nearly 24 hours as i was waiting for surgery. I just took my PD drugs with sips of water and my PD was perfectly controlled!
Hi, @Drew1.
Thanks for sharing this. I’m sorry to hear how tough the nights can be for you.
It’s really interesting what you’ve noticed about your meds overnight and how food affects things too. It might be worth having a chat with your Parkinson’s nurse or consultant about using the modified release tablets in the day, just to see what they think and what might work best for you.
We have some information on co-careldopa, including modified release tablets, on this page, which might be useful.
And, as I mentioned to Ed2, you’re always welcome to call our helpline and discuss any medication questions that you have with our specialist nurses: 0808 800 0303.
Take care
Parkinson’s UK Moderation Team
Sounds like your ready for deep brain stimulation,have you thought about going down this avenue
Hi Gus, thanks for your message. With regards to DBS, I don’t fancy it tbh but I may have no choice!
It is incredibly frustrating when the medication that is supposed to give you your freedom back starts feeling like the thing holding you hostage. That complete immobility after only an hour of relief is exhausting and makes it nearly impossible to plan a normal day. You deserve to have a consistent baseline where you aren’t constantly bracing for the next crash. See if you can get a priority appointment with your Parkinson’s nurse to discuss a more stable dosing schedule.