Crf


#1
I read this today:

http://medicalxpress.com/news/2013-01-onset-alzheimer-memory-loss.html

It's about Alzheimer disease and how exercise slows (and prevents) Alzheimer's disease. Apparently they discovered that during exercise CRF is released and this slows down progression.

So I went to search whether they did some experiments with CRF in Parkinson's disease. I found following article from 2007:

http://www.ncbi.nlm.nih.gov/pubmed/17650114

So yes, they did and results were very very good. Usually people treat rodents with some substance and then they poison their brains. However, in this research they gave CRF 7 days after poisoning and still it was shown to reverse lesions. So very promising, but I don't know whether there are clinical research done with this or whether there are meds based on this. I will try to find out and post here if I manage to find.

#2
I yet didn't find anything about CRF treatments. Apparently it is a peptide that doesn't pass the BBB. So you need neurosurgery to treat the brain with it. But Exendin-4 seems promising too:

http://www.ucl.ac.uk/pharmacy/research/NeurosciencesResearch/Neuroscienceongoing/neuroinflammation

I will keep searching and hope I find something more about CRF.

#3
A Korean group showed the mode of action of urocortin is via a cyclic AMP/protein kinase interaction in 2010:
http://link.springer.com/article/10.1007%2Fs10059-010-0132-x?LI=true
I cant find anything recent by the group (at UCL) that wrote the original papers (2007,2009). In one part of the experiments the urocortin was administered 7 days after the toxin, still giving beneficial results.........but given that recent paper from Astra Zeneca I am very dubious until the experiment is repeated with the overexpressing alpha-sync model.