Thanks for the replies and the useful information,but most of all for the "take care".
Need to absorb and rest my Brain(whats left of it)
Thanks again
All the best
Titan
Hi Ray,
Thanks for the replies and the useful information,but most of all for the "take care".
Need to absorb and rest my Brain(whats left of it)
Thanks again
All the best
Titan
Thanks for the replies and the useful information,but most of all for the "take care".
Need to absorb and rest my Brain(whats left of it)
Thanks again
All the best
Titan
Thats the spirit, we'll look back and laugh.
Like that woman who got her face ripped of by her pet chimp. She got a face transplant and it was good to see her laugh as she recounted the story.
At least it looked like she was laughing.
Like that woman who got her face ripped of by her pet chimp. She got a face transplant and it was good to see her laugh as she recounted the story.
At least it looked like she was laughing.
Mind you, I'm still convinced that every PD patient will have their own individual DA threshold, beyond which they WILL succumb to the overpowering and irresistable pull of OCDs, whether they realise it or not.
These could be gambling, libido or anything, so take care all!
These could be gambling, libido or anything, so take care all!
Hi Ray,
I think you've made your point. Thank you.
I think you've made your point. Thank you.
Surprised you felt the need to make that one then.
G'night, sleep well.
G'night, sleep well.
Hi all.
For those who know my story and opinions inside out, and are - quite frankly - sick to death of hearing them, the reason they get re-aired frequently is not just to irritate you, or even to boost my own ego.
It is because by doing so over the last few years we have managed to catch a considerable number of very serious DA/OCD cases - rescuing many a marriage, family or bank balance in the process - just in time. Many a catastrophe has been prevented, and more than one suicide avoided.
You can read the headings and you know the content. If you don't like it, don't read it. As long as worried newbies find my contributions useful - and they DO - I will be here.
Cheers,
Ray.
For those who know my story and opinions inside out, and are - quite frankly - sick to death of hearing them, the reason they get re-aired frequently is not just to irritate you, or even to boost my own ego.
It is because by doing so over the last few years we have managed to catch a considerable number of very serious DA/OCD cases - rescuing many a marriage, family or bank balance in the process - just in time. Many a catastrophe has been prevented, and more than one suicide avoided.
You can read the headings and you know the content. If you don't like it, don't read it. As long as worried newbies find my contributions useful - and they DO - I will be here.
Cheers,
Ray.
Morning Ray,
Just eating a slice of humble pie with my cornflakes
Have good day. Glad you're topping up the vinegar too, in cafe.
Just eating a slice of humble pie with my cornflakes
Have good day. Glad you're topping up the vinegar too, in cafe.
I hope you put some vinegar on your cornflakes today!
Cheers,
Ray.
Cheers,
Ray.
It's better than someone wizzing in your chips.
Hi all.
Most of the newbies joining us recently have been early-onset, usually in their late 40s. I’m not sure whether this is because (a) patients are now getting the condition earlier in their lives, or (b) the medical profession is getting better at diagnosing Parkinson’s earlier.
Either way Neuros seem to be almost exclusively prescribing dopamine agonists to these “youngsters” nowadays, telling them that over the years the effectiveness of Levodopa falls significantly, and that they therefore intend not to introduce Sinemet (etc) yet, but will wait for a few years until it is really needed.
In choosing DAs it would seem that most Neuros are STILL not warning patients of the risk of OCD side effects from DAs, and that those who ARE do not provide all the gory details of how serious these OCDs are, nor how high the number of patients who fall foul of them is.
Those DA newcomers who join or follow this forum will (I hope) soon become aware of these risks, and start asking questions of their Neuros. What will happen to those who are unaware of us, God only knows.
Ray.
Most of the newbies joining us recently have been early-onset, usually in their late 40s. I’m not sure whether this is because (a) patients are now getting the condition earlier in their lives, or (b) the medical profession is getting better at diagnosing Parkinson’s earlier.
Either way Neuros seem to be almost exclusively prescribing dopamine agonists to these “youngsters” nowadays, telling them that over the years the effectiveness of Levodopa falls significantly, and that they therefore intend not to introduce Sinemet (etc) yet, but will wait for a few years until it is really needed.
In choosing DAs it would seem that most Neuros are STILL not warning patients of the risk of OCD side effects from DAs, and that those who ARE do not provide all the gory details of how serious these OCDs are, nor how high the number of patients who fall foul of them is.
Those DA newcomers who join or follow this forum will (I hope) soon become aware of these risks, and start asking questions of their Neuros. What will happen to those who are unaware of us, God only knows.
Ray.
Perhaps those newcomers (welcome!) who have only recently been diagnosed, and who have been prescribed drugs from the "Dopamine Agonists" group, could let us know here whether they were consulted, or just TOLD what they were going to be given.
Also whether they were informed that 1 in 4 patients prescribed DAs will suffer Obsessive Compulsive Disorders (OCDs) to some extent, and these have in numerous cases gone on to totally destroy lives, careers and families.
Thanks.
.
Also whether they were informed that 1 in 4 patients prescribed DAs will suffer Obsessive Compulsive Disorders (OCDs) to some extent, and these have in numerous cases gone on to totally destroy lives, careers and families.
Thanks.
.
Hi,
Have some thoughts going round in my mind concerning the DA issue,in particular some thoughts about those who take DA,s and the varying degree of effect/reaction they have.In particular,in the light of finding out the Azilect with Anti depressants problems,it has me wondering.
When i started taking Azilect,i took it on its own for the 1st couple of weeks,then introduced Mirapexin.Now,there are differing views on exactly what benefits Azilect has.It is meant to slow down the progression of pd,yes.However,there are many contrasting reports from those taking it.The fact that some people can,t tolerate it,or makes others ill indicate it is quite a powerful medication,it performs a specific function which in my case works.
On its own,the Azilect alleviated my symptoms.Improved my writing,give me a boost,pepped me up.It was subtle,not dramatic,but it was there.Now my question is this.To what extent does the combining of Azilect with a DA,in my case Mirapexin,effect or alter the the strength or function of the DA.In other words can the Azilect with DA combination actually heighten/increase the likelihood of pwp developing OCD,s.It seems logical to me,have there been any studies.
Bearing this in mind and having returned to gambling on Saturday following 2 weeks abstinence. I got chatting to a pwp/acquaintance about my recent developement of OCD tendencies.Guess what,he is having the same problems but with machines,he recognises but is unable to stop.
The big difference is,he is taking Sinemet,not a DA.Now i know they can cause OCD behaviour but understood this to be infrequent.That leaves one common factor connecting us THE AZILECT.What effect is the Azilect having,how much impact is this having on those with OCD,s,sitting there quietly in the background,whilst all the blame is placed on the DA.I believe that the Azilect does add to or maybe increases the effect,contributing to the OCD behaviour of those taking it.
The other person i mention is in his late 50,s,in case relevant.I would be interested if anybody had any thoughts on this matter.
All the best
Titan
Have some thoughts going round in my mind concerning the DA issue,in particular some thoughts about those who take DA,s and the varying degree of effect/reaction they have.In particular,in the light of finding out the Azilect with Anti depressants problems,it has me wondering.
When i started taking Azilect,i took it on its own for the 1st couple of weeks,then introduced Mirapexin.Now,there are differing views on exactly what benefits Azilect has.It is meant to slow down the progression of pd,yes.However,there are many contrasting reports from those taking it.The fact that some people can,t tolerate it,or makes others ill indicate it is quite a powerful medication,it performs a specific function which in my case works.
On its own,the Azilect alleviated my symptoms.Improved my writing,give me a boost,pepped me up.It was subtle,not dramatic,but it was there.Now my question is this.To what extent does the combining of Azilect with a DA,in my case Mirapexin,effect or alter the the strength or function of the DA.In other words can the Azilect with DA combination actually heighten/increase the likelihood of pwp developing OCD,s.It seems logical to me,have there been any studies.
Bearing this in mind and having returned to gambling on Saturday following 2 weeks abstinence. I got chatting to a pwp/acquaintance about my recent developement of OCD tendencies.Guess what,he is having the same problems but with machines,he recognises but is unable to stop.
The big difference is,he is taking Sinemet,not a DA.Now i know they can cause OCD behaviour but understood this to be infrequent.That leaves one common factor connecting us THE AZILECT.What effect is the Azilect having,how much impact is this having on those with OCD,s,sitting there quietly in the background,whilst all the blame is placed on the DA.I believe that the Azilect does add to or maybe increases the effect,contributing to the OCD behaviour of those taking it.
The other person i mention is in his late 50,s,in case relevant.I would be interested if anybody had any thoughts on this matter.
All the best
Titan
My husband was also taking Azilect alongside Mirapexin and Amantadine when he had his awful obsessive/compulsive problems.
Dear titan & libra lady, I totally understand your concerns about drug interactions. I am not a neurologist but this is my understanding. I am more than happy to be corrected.
Drug interactions are not detected when a drug is approved.Later studies with a very small sample population & not repeated (therefore not considered scientically reliable)suggest:
Azilect alone - OCD most likely in 1st month in males of around 40 years of age
Most co-used drug = mirapexin. No interaction found
Sinemet alone - OCD peak after taking for about 2 years , no difference between the sexes, age roup 50-60. Most co-used drug = mirapexin
Azilect + sinemet - the azilect may increase existing dyskinesia, postural hypotension, hallucinataions
From forum members reported experiences, this is not particularly helpful. It is your experience that matters, & I say well done you for recognisisng it, thinking about it & talking to your neuro/nurse about it
Drug interactions are not detected when a drug is approved.Later studies with a very small sample population & not repeated (therefore not considered scientically reliable)suggest:
Azilect alone - OCD most likely in 1st month in males of around 40 years of age
Most co-used drug = mirapexin. No interaction found
Sinemet alone - OCD peak after taking for about 2 years , no difference between the sexes, age roup 50-60. Most co-used drug = mirapexin
Azilect + sinemet - the azilect may increase existing dyskinesia, postural hypotension, hallucinataions
From forum members reported experiences, this is not particularly helpful. It is your experience that matters, & I say well done you for recognisisng it, thinking about it & talking to your neuro/nurse about it
I am so sorry, I forgot to include that the same study suggested that OCD in those taking mirapexin alone was most common in females aged 50-60
I also forgot to say that I had nothing to with this research & in no way eiher endorse or refute the suggested findings
I also forgot to say that I had nothing to with this research & in no way eiher endorse or refute the suggested findings
Hi,
Well it doesen,t take much looking to read that Azilect and mirapexin or any DA,s both increase dopamine levels.To my mind,that is like taking extra mirapexin.To what extent i don,t know.Most reports have it listed on its own or in conjunction with sinemet,or other levadopa med.Does this not increase the risk of catastrophic compulsive disorders.To what extent,how can it be gauged,all i know is i had relief of symptoms with Azilect on its own,so when Mirapexin was added it was like a miracle.
Don,t see this talked about much,is it not an important factor
have i got it wrong,the exact workings and benefits of
Azilect are pretty much in their early days
Us who are taking it are Azilect guinea pigs
All the best
Titan
Well it doesen,t take much looking to read that Azilect and mirapexin or any DA,s both increase dopamine levels.To my mind,that is like taking extra mirapexin.To what extent i don,t know.Most reports have it listed on its own or in conjunction with sinemet,or other levadopa med.Does this not increase the risk of catastrophic compulsive disorders.To what extent,how can it be gauged,all i know is i had relief of symptoms with Azilect on its own,so when Mirapexin was added it was like a miracle.
Don,t see this talked about much,is it not an important factor
have i got it wrong,the exact workings and benefits of
Azilect are pretty much in their early days
Us who are taking it are Azilect guinea pigs
All the best
Titan
But isn't the problem the unknown properties of DAs, not dopamine levels?
Yes, since the aim of giving PD medication is to raise dopamine levels from abnormally low to ones that produce acceptable mobility, then side effects are more likely to be due to the nature of the drug itslf and interations with other drugs than dopamine level (I think)
No, I disagree. That is the way L-Dopa based PD medication works, by hopefully replacing some or all of the missing dopamine.
My understanding is that dopamine agonists, on the other hand, are compounds which activate dopamine receptors in the absence of dopamine. They activate the target receiving neurons directly, without utilising the normal dopamine-releasing neurons at all.
Two totally different solutions to the same problem.
Ray.
My understanding is that dopamine agonists, on the other hand, are compounds which activate dopamine receptors in the absence of dopamine. They activate the target receiving neurons directly, without utilising the normal dopamine-releasing neurons at all.
Two totally different solutions to the same problem.
Ray.
point taken. Maybe I should have said the aim was to increase rhe dopaminergic action in the brain?