Hi Sparkey (Jean).
Cobeneldopa is a well tried and well used PD drug that has been prescribed for many years. I've been on it in the form of Madopar, since DX five years ago. I started with 2 x 62.5 but am now on 4 x 125 plus a CR (controlled release) at night.
Now - the thing I have established, especially being on this forum is the massive variation in symptoms, reactions, medication and attitudes to this strange and unimaginable disease that has been inflicted on us.
I can't offer professional advice but based on my experience, don't up your level of cobeneldopa until instinct tells you must. As you probably know cobeneldopa consists of 2 ingredients - Levodopa, which contains dopamine to supplement the loss of this important chemical released naturally from ones brain. It also contains Benserazide which is an agonist, designed to help get the Dopamine from the tablet into the brain, rather than being absorbed in the gut. Overdosing sometimes causes the same symptoms as under dosing, so it's tricky.
I find the forum very heartening, informative and useful and the stoicism and optimism of people amazes me. Yes, you will read a few Anglo Saxon expletives but it's a good way of letting off steam.
There are a lot of people that have had this disease for many years (some twenty or more) and have lived very full lives. My sister has had It for 17 years.
So good luck keep as fit as you can and I wish you well.