Insomnia since increasing Sinemet


#1

I've not had any problems with sleeping since diagnosis just under 4 years ago.  However in May my nurse advised me to increase the dose of Sinemet from 62.5 mg x 4 to 125mg x 4 to help with fatigue although I haven't seen much difference.   Since then I've been struggling with sleep. I often find myself awake at 3.00 am or I awake after about an hour and then can't get back to sleep.  

I'm wondering if it's a coincidence or if the increased Sinemet could be the cause.  When I'm tired I feel edgy which prevents me getting to sleep,  its a vicious circle. 

Just wondering if anyone else has had similar experience. 


#2

Hi Bluebarb

I've had sleep problems from the start, I do take sinemet now, but I haven't noticed any link. It seems to be really common with peewips to have erratic sleep patterns. I've been told that parky can turn your body clock upside down. Sometimes I get 2 sleeps at night with 2-3 hours awake in the middle, other times I have a siesta in the afternoon. Really important thing is not to get overly worried about it and try to find a pattern that will work for you.

good luck

Mosie


#3

Thanks Mosie,

It's really frustrating, when I never used to have a problem sleeping, but I guess that's the nature of Parkinsons.

As mentioned in another thread, I'm going to try changing my tablets a bit so that I have a smaller dose, but more often to see if that helps. 


#4

I have had problems with insomnia for about 10 yrs now due to pain from my spine  and severe arthritis and have been given sleeping pills which really helped until I was diagnosed with PD 4 months ago. I started taking Sinemet and after two weeks was told to double my dose but since then I am lucky to get  3 hours sleep a night.

I am going back to see my neurologist on monday so I will mention this to him as am so tired al the time 


#5

I saw a new neurologist 3 weeks ago, who said I was over medicated and increasing Sinemet isn't the way to treat tiredness, I'm gradually reducing back to 62.5 x 4, and I have been sleeping better. I have also been taking amitriptyline  20mg at night for about 3 years to help with discomfort/pain in my leg at night but he wants me to stop that as well to see if it helps my fatigue.  Just hoping that doesn't affect my sleeping. 


#6

amitripyline helps you sleep ! taking sinemet before you go to bed is no good for you as it keeps your brain active " alert " making it hard to sleep have a look at your last meds time before you go to bed !


#7

 

I've been on amitriptyline for a year too help with overnight pain and help me sleep, i started on a lower dose of 15 mg and im now on 25mg, i noticed for example if i took it mid evening 9pm+ then i'd drift off late too sleep 1 or 2 am, if i took it after dinner 7pm ish then i'd be alseep earlier and have a better nights sleep.

I still suffer from fatigue during the day though, that might be i'm trying too do something during the day too feel normal even if im not.


#8

i take my amitripyline at bedtime with my sleeping tablet & also take sinemet slow release at night time aswell !


#9

Thanks Gus, I've always taken my last Sinemet at 8.00 pm, but following recent posts,  including yours, about timing, I'm going to try taking  it earlier.  I'm a little apprehensive about stopping Amitriptyline in case it affects my sleeping but I guess I'll have to try.


#10

8.00pm is fine if you go to bed about 10 ...10.30pm, do not  understand the whole amitripyline thing tho !


#11

Neurologist  thinks Amitriptyline  might be contributing to the tiredness I've been having, though I'm not sure, its not sleepiness, more of a physical tiredness.  I guess I'll just have to try and see what happens. 


#12

you can only but try ! cant see 20mg of amitripyline is the answer but your life is in there hands they no best  ! hope you get to the bottom of the problem, I'm on 75mg & sleeping tablet  but no one is the same !


#13
I take duloxatine for pain in feet and legs and it works really well. I don't know if it has any effect on my deep patterns but I tend to sleep relatively well. Ask your GP about it. Cossy