My husband was diagnosed last week with Parkinsonism MSA and was started on Sinemet. I know it’s only been a week but there’s been absolutely no improvement at all. He’s now on two tablets a day. If anything I would say he’s getting worse. How long does it usually take before there is any improvement or is this a case of it’s not working with MSA?

Sorry I cant answer that . PD is the most confusing condition I have come across. And everyone is so different in response to medications? i was started on that, at 3 tablets a day, Quickly rose to 9 a day. And got some normality back. I do wish you and your husband some positive news soon. Just been one hit after another for you both lately.
Esme x