They simply said there was no significant difference. For 35p per day I personally will continue, even if just for the placebo effect
CoQ10 Trial Stopped Early
CoQ10 may not slow the progression of early Parkinson’s disease as many had thought. Last week the QE3 trial was stopped early. Now what?
CoQ10 is an enzyme that improves the function of the mitochondria, the “powerhouses” that produce energy in cells. It also “mops up” potentially harmful chemicals (“free radicals”) generated during normal metabolism. People with PD have low levels of this potent antioxidant in their mitochondria and also show impaired mitochondrial function. Levels of CoQ10 can be increased by taking supplements.
Early studies were promising. The QE2 trial which had 80 participants produced enough interesting data to suggest the value of a larger study. The QE3 trial was a very large study of 600 participants conducted at many research centers around the US and abroad. The goal of the trial was to find out whether CoQ10 could slow the progression of Parkinson’s disease.
Apparently, it can’t. The Drug Safety Monitoring Board (DSMB) determined that there was not a statistically significant difference among the control group, the 1200 mg group, and the 2400 mg group to justify continuing the trial. The trial was well implemented; there were no flaws in the methodology, and no safety issues. It’s just not the outcome we wanted!
So, back to our question. Now what? Parkinson’s patients are encouraged to discuss with their neurologists whether they should continue taking the supplement. There may, in fact, be other health benefits from taking CoQ10, such as for heart disease, cancer and strengthening the immune system.
Clinical trials are valuable whether or not the supplement or drug being tested proves efficacious. We learn just as much from failures as we do from successes. The QE3 trial proved that CoQ10 is not effective in delaying the symptoms of early Parkinson’s. Fortunately, there are many other therapies currently being tested that may be able to do so. So, let’s keep our hope alive!http://www.recentlydiagnosedwithpd.org/home/2011/5/25/coq10-trial-stopped-early.html