Hi jo h
Sorry to hear your husband is having difficulties with his meds.
This is not unusual however, and there is always an adjustment needed in most cases.
You've come to the right place for help as there is always someone who has had a similar experience.
I am now on Stalevo 125. 4 times a day after after 1 x 150 Stalevo 1st thing in the morning.
Previous to this my specialist allowed me to try different amounts daily to see which gave the best results.
(ie. Stalevo 100 x 4 daily + 125)
I'm sure somebody else will give you their advice on this subject.
Hang in there & wish your husband "all the best" from me.