I don't know, Gus.
our neurologist and Parkinson's nurse seem reluctant to recommend the CR version as they say it is unpredictable.
A larger dose is needed as not all of it gets into the system and that makes dyskinesia more likely.
My husband did insist on trying it at night to stop the unmediated state when in bed and struggling to turn over but found no improvement.
They both tell him that they are waiting for an effective alternative.This is our hope for Rytary...or IPXO66.
At the moment he takes Sinemet 8 times a day, every 2 hours to stay "on"
This is OK but he longs for the 1 a day Requip which worked very well but ruined our lives with OCDs!
I would be interested to hear of people's experiences with Sinemet CR and wonder if it is worth another go?