No need to apologise. You are right. I have had similar outburst in the past. Especially with the GM1 ganglioside study. This was something invented in the 80's. We are now 2013 and still a clinical phase III needs to be started. And even if this trial would give positive results, GM1 ganglioside will never be sold anyway because big pharma's want a pill form. So the MJFF is trying to make such a pill and as a consequence of that they are starting with such pills in preclinical trials on rodents. Worst part, they don't even know if this is going to work at all. When I found out about this, I had an outburst too.
On the other hand, there are other things that are being funded that will make a difference. For example, I know my father has a mutation in the GBA gene that gave him almost 7 times more probability of getting PD. This is one of the most common forms of familial PD. MJFF is funding Amicus therapeuticals. They found a chaperone that increases the expression of an enzyme that is lacking in people with mutation in the GBA gene: http://www.amicusrx.com/programs.aspx
. Tests on animals show this chaperone is very promising for PD linked to this specific gene.
There are also other studies that seem very promising. The biggest concern in PD is a-synuclein. Many treatments are in development to target a-synuclein. You have the Affiris vaccin; the Belgian company Remynd; ... and several others whose name I forgot. There is also LMTX for Alzheimer, which also shows preclinical efficacy for PD. Without the charity money we wouldn't have got this close to a cure. I honestly believe in 10 years PD will not be the feared disease it is at the moment. If you look at what is present in the pipeline and what is known about the disease, it is all more promising than ever. Nurr1 is another extremely promising lead. So don't worry. In the end, money is well spent. The only drawback is that we need 5-10 years before the current pipeline is available for PD patients.
So it isn't all that bad. By the way ... don't be too early with throwing away the neurotrophic factors: https://www.michaeljfox.org/foundation/grant-detail.php?grant_id=1069