Every neuro has their own preferred pattern of meds and every PWP is different so it's hard to know what is "best", Gus!
Our neuro, who rescued my husband from the DA nightmare and got him on to a very successful Sinemet regime told us that little and often is the best approach and the aim is to keep the Levadopa as constant as possible.
The Sinemet doses are every 2 hours and he takes 8 a day.(one and a half 62.5)
The morning Azilect is to slow the progress and Madopar dispersible is to be used as a rescue if eating out or needing a boost to get going in a crowd, eg cinema.( Max 3 a day)
The neuro thinks the slow release Sinemet now available in America but not UK will be a very useful med to extend the life of each dose.
Neither he nor our Parkinson's nurse think the current cr version is very effective and my husband did try it at night but found it didn't really work for him.
Stalevo is another option as the Entacapone extends the time it stays in the system but my husband had very bad side effects....a common reaction to the Entacapone evidently and couldn't take it.
I wonder why your doses and types of Sinemet vary, as this seems to be at odds with keeping the levels steady?
I think the future holds out the imminent arrival of better delivery...the patch in clinical trials and the long-awaited Rytary.
Keep asking questions and experiment if you are allowed!
Don't give up!