I started Opicapone on 4th January so about 3 weeks ago. Some benefits, but not what I was expecting.
My “ON” times are no better, still need to take Madopar every 2 to 2.5 hours. I have tried extending this time, but it is counter productive - I go OFF so much that I can’t move or function at all and it takes the next couple of doses to feel ON again. Also, I feel woozy, muzzy and have a bit of a headache in the mornings. My mobility during the evenings is very poor.
However, on the plus side - I sleep more soundly, and when I need to go to the loo during the night, my walking is better so I don’t take quite so long getting to the bathroom and back. Also, dry mouth, listed as a possible side effect, means I have less saliva and am drooling less. The best thing of all is that I have had no indigestion since stopping Entacapone which I had long suspected contributed to it. Generally my gait initiation seems very slightly better.
So, on balance, I hope to continue Opicapone. Hoping that my ON times will yet extend. *