Hi all, (inc researchers, as this drug is very new).
Opicapone, a brief feedback.
Note: This report is merely my observations. The advantages, disadvantages and side effects may entirely different for others. No claims are made for the drug, merely its effects on me.
See also first my report (above) of 4th Oct.
There is now a reasonable amount of empirical data (over twenty days) to say that although I still have switch-offs most days, there has been a significant reduction in length and severity of switch-offs.*This is clearly to my advantage.
There has been a perceived small decrease in my level of painful Distonia.
*Note: There has been two bad switch-offs in the last week.
Recorded (assumed as possible) side effects:
Slight increase in constipation? No problems after one week.
An increase in severity and frequency of narcoleptic (deep brained) headaches. (A complex issue, that cannot definitevly be assigned to Opicapone).
Slight increase in level of existing Atrial Arrhythmia and Ectopic heart - beats but not fully assigned to Opicapone.
Increase in propensity to lose control of tongue movement?
A slight increase in dyskinesia?
When I first started taking Madopar, as the dose was gradually increased it seemed as if, to my advantage my creative abilities and abilities to reason, increased. To my disadvantage my anxiety levels increased slightly. This may of course be entirely coincidence but subjectively I don’t think so. As these effects have increased so have my narcoleptic headaches and my fatigue level.
Since taking first Safinamide, (for me not effective) now Opicapone my mind activity and creative ability have again increased to a point where my mind finds it difficult to shut down, to relax and my anxiety levels have again increased. So the narcoleptic headaches have remained and become more severe. I’m still hoping this is merely a transitory and temporary problem.
I do not take this drug after 6 pm as it affects my ability to sleep.
Because of the potential seriousness of the narcoleptic headaches. I’m considering asking for a scan to rule out other possible causes.(My identical twin brother suffered a massive bleed to the brain 2 1/2 years ago. (Post-mortem concluded Cerebel Amyloid Angiopathy)).
An Aside: (Modification to last report, 4th Oct).
It would seem the more surplus Dopamine floods ones brain areas, i.e. Particularly the part of the brain that controls, thought processes or mind activities and cognitive skills, It seems to create additional neural activity, such as creativity, anxiety, addictive behaviour, etc, etc. Hardly scientific but one way for a layperson to look at it.
Hope this is useful,