Parkinson Medicine less effect

My father is taking Co Careldopa 25/100mg 3 times a day. The medicine seems to become less effective over time with constant use, is there any better drugs he could possibly be prescribed to stop being ‘turned on & off’ (pauses between 10seconds to 2minutes) while walking.

Hi @MHD, :wave:

Welcome to the forum. :slightly_smiling_face:

Drugs like levodopa can be extremely helpful in managing movement symptoms. But over time, their effects become less constant. Dealing with off states in Parkinson’s can be very distressing so I’d recommend that you speak to your Dad’s GP or Parkinson’s nurse about this so they can look into his medication. Our research team posted an article on the on and off states and spoke to a specialist doctor about it to talk about the emotional stress which I think will provide you with a lot of useful information. You can find this here -

For additional information and support, feel free to contact our free and confidential helpline on 0808 800 0303. Or you can email us at [email protected].

Best wishes,

Could i speak to his GP without him being present at the appointment?