This recent Cambridge research “in understanding the role of a key protein called alpha-synuclein” in PD, is very much in tune with this Ambroxol for PD study statement:
“Upregulation of brain cytosolic/lysosomal GCase activity may reduce α-synuclein levels, mediating a neuroprotective effect in patients with PD both with and without GBA1 mutations…Ambroxol administration has also been reported to increase GCase activity and reduce α-synuclein levels in vitro and in vivo.”
Very glad I have stuck with Ambroxol for a year now, which is still consistently keeping me clear of brain fog, reducing my freezing episodes and their severity, benefiting me in some small motor functions like typing and facial animation, eliminating my shoulder nerve pain, and enabling me to stay on a lower dose of meds (& fewer). For me that is slowing my PD progression. Very much looking forward to further research confirmation next year when the findings on Ambroxol for PD dementia are published (link below).
In the meantime, I plan to absolutely continue taking Ambroxol (which my neurologist is aware and is fine with), as there is no way I’m going to risk it becoming more irreversable as the scientists postulate below, with something as well tolerated as it is:
“…it is not known when during the natural history of PD the first intracerebral α‐synuclein pathology appears and whether there is a “point of no return” beyond which the damage to the neural systems affected by synucleinopathy can no longer be protected or revived, even with the most effective therapies. As mentioned earlier, it is currently believed that α‐synuclein pathology begins to develop during the PD prodrome, and by the time motor symptoms have appeared the aggregates are widespread in the brain.”
PS, as a kid I watched my maternal grandmother die slowly from PD as she fell into severe dementia from it, and then I watched my mom slowly die from dementia over a number of years. We have better medicines today to hold off what happened to my grandmother, but there’s no way I’m going to stop taking Ambroxol if there is even the slightest chance it is found to be 1/2 as effective as I think it is in slowing PD progression.