Just thought that those of you that like "powerpoint-logic" might like to see the following presentation on ProSavin: http://www.oxfordbiomedica.co.uk/userfiles/file/presentations/ProSavin_Interim_Data_Analysis_December_2011.pdf
I personally quite like slides 9 and 10 (factual data
). My understanding of it is that :
1. ProSavin seems to produce a very important beneficial impact in the first 3 months of treatment. The impact is positive for all stages of PD they tested, but it seems to be particularly strong for those in advanced stage of PD.
2. The impact from month 3 to 6 is still beneficial but much smaller. By the end of month 6, the PD symptoms are around 33% better than at the start (as measured by the UPDRS scale).
3. After month 6, PD seems to start progressing again (symptoms get worse), but they seem to progress at the "normal" rate from the 33% lower point one got to in month 6. In other words, ProSavin seems to take us back a few years in our PD development path. It's impossible to tell from the data shown how many years one "goes back", but if you asked me to guess from the very little data shown, I'd venture somewhere between 2 to 5 years back (but, of course, this is very, very rough guess and might be totally wrong).
I was also encouraged by the mention in the last slide that "Enhanced construct identified; could provide more than 10-fold increase in DA production" - which suggests they might be looking at test an even better version!!
So, while none of these results seem to be fully confirmed yet (they need to run more tests), it all sounds very encouraging to me. My applause to the team working on this - I personally find it very encouraging !!!
Warm regards to all,