I've been experimenting with Safinamide (Xadago) in conjunction with Madopar (Co-beneldopa) on and off, for over six months now. I think it may reduce length of switch-offs. But it does seem to increase slightly painful Distonia (I'm not sure). From my tests with this drug there's a lot of conflicting evidence on the merits of it.
My prescribed intake of Madopar is now 5 x 187.5 mg per plus 250 mg CR at night. The length of time of my switch-offs has increased recently as have frequency of them. My level of akynesia during S/O s has also increased considerably. These changes are happening, as far as I can ascertain, with or without the Safinamide.
I'm going to try a longer period, say six months, on the Safinamide, but if things clearly get worse, I'll drop it.
Fighting back, in any way I can is positive.
Does anybody else have experience of the drug?