I've actually been wrestling with these thoughts myself.
I was diagnosed about 2 years ago and it took more than 12 months to find a package of drugs that (more or less) help without too many issues. In that time I've taken part in a number of research studies (ie studies where I'm evaluated, tested, given blood, spinal fluid, skin, etc but do not take any new drugs.)
But I'm starting to think maybe its time to take part in a clinical trial (ie where a new drug or placebo is given for a reasonably long period.)
Now I'm not eligible for the Bristol GDNF trial - which is probably good news, because I'd be frightened to join that (and I think my wife would go ballistic if I suggested volunteering to have holes drilled into my skull!!.).
But maybe something I can swallow or have injected just into my skin, would be acceptable. Why would I? Well partly to benefit the future community but also, the next likely big advance in PD drugs will be neuroprotective, which means they'll stop you getting worse but wont make you better.
So, should I take part now, in the hope that I can remain at my current level, rather than wait until I've deteriorated further? The chance of a treatment which can actually restore neurons is probably further away.
Though then again I remember the disastrous clinical trail of TeGenero's TGN1412 at Northwick Park in 2006 - and think: "what if??"
But I think I may look around over the next few months and see if I can find an upcoming trial of a drug which looks hopeful but isn't too scary, and sign up. Anyone out there got any suggestions (in the southern part of the UK)?