My local Boots usually dispense the yellow oval Sinemet Plus 100/25 produced by Quadrant (in Bolton) I've had no issues with them other than the central label on the foil packaging hinders removal of the tablets, when I'm OFF.
Boots have occasionally issued the pale round tablets from Merck Sharp & Dohme. I find these are much easier to get out of the foil pack.
I had read somewhere on the forum that PwP have varying reactions to who produces their Sinemet Plus so I decided to try a week using only these to test this out. I also wanted a more robust reason for asking Boots to supply the MSD ones, other than being easier to get out of the foil.
After just four days (20 tablets in all) it was like I hadn't taken any Sinemet.
I switched back to the yellow ovals and I'm back on track again.
Anyone else found who produces their Sinemet Plus affects how effective it is and potentially which side effects you get?
Also wondering if this applies to other drugs and whether in some (maybe not so small) way contributes to the variety and complexity of our prescriptions. Are prescription changes being triggered by who produces the drugs rather than just the progression of our underlying PD symptoms?