My wife has had Parkinsons for over 20 years and over time has had a number of different drug regimes. She has though for sometime been on Stalevo ( 100MG 6 times a day) , Pramipexole (now at 2.62mg once daily). Overnight she takes Co-Careldopa MR (50/200MG 1 Tablet).
The problem is that the overnight medication appears to cause her real issues with her abdomen / stomach with extreme discomfort in the morning when she first wakes up and does not get any better until she has managed to empty her bowel (She has been prescribed Fybogel to help her digestion). She had similar problems a few years ago and stopped taking the Co-Careldopa, taking additional Stalevo at Midnight and 3AM which was not conducive to her sleeping (or me!). When she returned to the Co-Careldopa it seemed to be fine but the problem has returned and seems to be getting worse.
Question really is is this common? Is there an alternative Slow Release Medication instead of Co-Careldopa that might help?