Splitting "CR drugs"


#1
This has been mentioned before. I apologise, I cannot track down the thread
I do not mean cutting the tablets in half, but taking them at different times. I am prescribed 8 & 4 mg requip XL to be taken 8 hours apart. If they do their job slowly over a 24 hour period I just can't understand why. Is it because there is a plan to reduce dosage? Can anybody enlighten me?. I'm afraid that I simply took the neuros instructions as gospel

#2
Hi.

I've always assumed that the larger dose is taken before the busiest part of the daily cycle, i.e. when there will be the biggest demand for, and take-up of, the chemicals. Then the smaller doses before longer, quiet periods, just to keep you ticking over.

It's rather like eating a 16oz steak and a pudding just before you go to bed. When you're asleep there won't be any demand for fuel so it'll just turn to fat. But if, a couple of hours after the big meal you're going to burn it off doing some heavy building work, you'll need it.

Ray.

#3
Hi AB
i dont believe that requip xl actually works constantly for 24 hours. most drugs seem to be in the system in a bell curve. the second dose might be to fill in the downside of the bell curve to make a plateau. according to the FDA the median time to peak concentration is 6 to 10 hours,ie usually about 8 hours.
it might look a bit like this where v is 8mg and is 4mg.


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xxxxxxvvvvvvvvvvvvvvvvvvvvxxxxxxxx
vvvvvvvvvvvvvvvvvvvvvvvvvvvvvvvvv

eating a fatty meal also increased the AUC (area under the curve) and the c max.
http://www.drugs.com/pro/requip-xl.html

selemat malam

#4
terima kasih turnip
Just stopped myself from sending an urgent message asking what the o's were about. Rearrangement of glasses & distance between eyes & screen got it sorted.
Am enjoying your travelogue, possibly more than you are enjoying travelling?
best wishes (tinged with not a little envy) to you & your family