Hi again Mister X
I think many researchers would agree with you that trying to reduce the production of the alpha-synuclein protein inside nerve cells is barking up the wrong tree and won't lead to effective treatments for Parkinson's.
There is a lot of debate and conflicting views in other areas of Parkinson's research too. For instance, some people are very excited by the prospect of stem cell therapies - while others think they are wasting their time. I find it amazing actually because whenever I hear a scientist speak I hear a different perspective on Parkinson's and what the future might hold.
I guess it might sound a bit disheartening that Parkinson's researchers can't agree on a best way forward but actually I think it's one of the greatest strengths of the field at the moment. Researchers all over the world are working to solve the same problem but looking at it from so many different angles and challenging each other's findings at every stage.
The truth is in science we can never be sure who's on the right track and who's heading down a blind alley. But I think it's encouraging that there are so many different ideas being pursued (even though some of them will undoubtedly fail!).
One thing we can all agree on though is that current animal models of Parkinson's are not good enough. They don't reflect the slow, progressive loss of nerve cells inside the brain and they can't predict accurately whether a new treatment is going to be beneficial to people with Parkinson's. Genetic models of Parkinson's are being developed but there's no perfect model yet.
That's why developing better animal models is a key part of our research strategy;www.parkinsons.org.uk/researchstrategy
Hope you had a lovely weekend.