If electrical synapses stimulate the feeling of tiredness, it will be through the body's physical state, even if induced by aspects in PD, medication or just the result of physical exercise.
Once put on medication, in the early days, I seemed to get the tiredness signals more often.
That said, after Physiotherapy to build up and balance muscle tone throughout the body, the frequency in such periods have diminished to the odd occasional periods.
And when these odd occasions occur, I take a Borage Oil capsule and benefit from the pick you up aspect it brings me.
In my opinion, it is a matter of striking the right balance and pacing yourself on a daily basis.