Thank you for your input, it is very useful. I tried entacapone about three years ago, when I was on a much lower level of Madopar and my PD symptoms hadn't progressed so much. It didn't suit me and didn't seem to help in any way.
I see my GP next week and I will ask the question you posed, viz’ why tolcapone rather than entacapone?
Now symptoms have got really quite bad, particularly switch-offs and Distonia I’m prepared to try entacapone again but will hold off until I’ve seen how this Safinamide works (which is expensive) as since I have recommenced taking it there has been some marginal improvement. I'm on over a 1,000 mg of Madopar every 24 hours.
I read the reports from BB about the massive change DBS has made to her life. As I’m coming up to 80 that is not an option however.
From what I’m hearing tolcapone may be a bit dodgy.
Just read your input SA, nice to hear from you and very helpful as always. Interesting about your GP and his view of Safinamide. Yes PD what's the latest gen?