Trial Testing Low-dose Psychedelics in PD

About Parkinson's and health Treatments and therapies
1

This would be an interesting trial to be a part of:

"The trial’s primary goal is to examine the effect of low doses of psilocybin and LSD on cognitive and emotional dysfunction in patients with Parkinson’s, as well as to understand their mechanism of action.

Specifically, the trial will assess the safety and efficacy of repeated low doses of psilocybin and LSD and their effects on well-being, emotional and cognitive attention, and biological markers of neuroplasticity, which is the ability of neural networks — the large-scale intertwined circuits that connect nerve cells to one another — in the brain to grow and reorganize, such as individual neurons making new connections.

Secondary goals include the effects of low doses of psychedelics on cognition performance measures of memory and executive functioning, which are commonly impaired in Parkinson’s, as well as emotion regulation and biological markers of well-being."

https://parkinsonsnewstoday.com/2020/12/04/silo-pharma-plans-phase-2b-trial-of-psychedelics-in-parkinsons/

2

That’s great. However, it’s important to remember that Parkinson’s disease is a complex disorder. There’s no single treatment that works for everyone.

4

I’ve heard a few people mention surprising benefits, especially with mood and motivation, but I’d love to see proper data. Curious about the long-term safety and how it affects movement.

5

Thank you for sharing with the group, Woitake, and welcome to our forum. We’re sure that others will share their experiences with you and we hope you find support through this community.

In case it’s helpful, we have some information on using complementary therapies in Parkinson’s on our website here: Complementary therapies | Parkinson's UK We’d always recommend speaking to a health specialist as well to ensure that you’re getting advice that’s right for you.

You may also find our free, confidential helpline useful. Our trained advisers can offer support and advice, and you can ask to speak to one of our Parkinson’s nurses: 0808 800 0303.

Take care,
The Parkinson’s UK Moderation Team

6

I’ve been looking into similar approaches and found some people chatting about microdosing and its possible effects on focus and mood. I came across https://gomicromagic.com/ where experiences are shared, including from folks with chronic conditions. It’s not PD-specific but still interesting to see what others report. Always good to stay curious and keep sharing what works or doesn’t.

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