Just an idea. I asked chatgpt if it was ever done but it says nobody ever did it. The idea I have is the following. Alpha synuclein and its aggregates are responsible for the disease and its progression. Now what happens if you can send a beam of some sort through the brain that makes alpha synuclein vibrate at its eigenfrequence or the eigenfrequence of its aggregates ? Could it make these proteins/aggregates dissolve which would stop them for causing further damage ?
Sounds very interesting, but way out of my league.