I was diagnosed in late 2017 and started the drugs at the beginning of 2018. I’m finding that the sinemet/kinson wears off after 3 hours now. Actually I began to notice that about 3 months ago. I already take 1 tab 4 times a day, along with amantadine and premipaxole, having gone up from 3x a day initially. What next then? Taking 2x sinemet per dose? I notice the wearing off mostly in my gait and how it shortens. (It’s started to cause muscle problems in my feet and and knee and an Achilles problem). The premipaxole has become less effective too. When I started taking it it did wonders for my facial masking and making it easier to smile and raise my brow, now it seems to do little.
I’m seeing the pd nurse in a few weeks time but this is really playing on my mind… I thought I had a much longer “honeymoon” than this?