Desperately trying to help mum who was diagnosed about 4 yrs ago. She takes 1 1/2 sinemet 125g 5 times per day but it is now slow to take effect and wears off quickly. She takes it at 3 hrly intervals with a madopar first thing in the morning and a single sinemet CR at bedtime. Effectively she is probably getting an hour and a half 'on'. So is feeling dreadfully desperate for most of the day.
MumS off times manifest as severe anxiety, bloating, panic and stomach pain. It's is incredibly distressing for her and awful to witness.
My question is: would it be beneficial to spread the sinemet out so that she takes a full tablet at the scheduled time but then take the half dose about an hour before she is due her next full dose to try to head off the off times ?
I am desperate to help her, has anyone tried this or have any other suggestions?
Many thanks everyone