I take Sinemet every 2-2,5
I accept that the consultant knows best most of the time,and I largely follow his suggestions, within the boundaries set by him, but I like to keep some control overall Any changes are always started on a trial and error basis. My drugs regime takes into account my own experiences over the years (Mirapexin since 2001, Sinemet since 2005) on these drugs and on the experiences of fellow Parkies, attending support groups, and on what I've read on other forums and publications on medscape, uspharmacist,etc. Levodopa is very short working., in my case it comes into effect after 20-30 minutes if taken on an empty stomach . It then gives me one hour , after that I could go "off"" at any moment or (rarely) function perfectly normal, even right until the next pill's beneficial effect.is felt. Of course the only time during the day my stomach is truely empty is with the first dose.. I find that in the course of the day food can build up and sometimes is slower to digest and pass through. I think that this could be the reason why later in the day you often find that, even when you have been very careful to leave a gap of more than 90 minutes between the last food bite and the next pill intake. Probably for some people eating small amounts of food (snack size) all through the day is best. I haven't tried this as my appetite is quite strong , and these mealtimes are also the occasions when you eat with friends or family, which makes it harder to stick to a tight time schedule.