This wearing off or going into switch-off is weird. Trying to get some sort empirical data for using co-beneldopa (Madopar) is difficult as there seems to be so much randomness to the attacks. Sea Angler is right, having the 62.5 capsule gives one more flexibility and I also recommend you have 62.5 dispersible in your armoury (excuse the battle metaphor) as it can be a useful boost.
I'm on 187.5 mg of Madopar x 5 a day plus 250 mg slow release at night. I vary that somewhat depending on symptoms and how I feel. I guess I use some sort of instinctive process. What doesn't make sense is I can have a switch- off just an hour after my dose or sometimes go five hours (just for experiment) before the dose wears off. It might pay you try sticking to the total daily amount plus or minus 10 to 15 percent. But vary your timing a little, to suit the situation.
I can sometimes fight my way out of a switch-off. For instance, yesterday I could barely walk and using two sticks I forced myself to do some work in the garden. It was slow, ponderous and probably dodgy. After half an hour I felt reasonably ok and with rests achieved the task. Other times I just have to give into it and sit in my chair until I improve. I hope this doesn't sound all to pompous.
Carolineb211. When my switch offs start, just like you I get a weird tingling sensation, almost like an inner nerve tremor, also my mouth seems to fee a strange pulling sensation. In the space of five minutes I go from relatively ok to being almost immobile.
This strange disease has no easy solutions and age is a factor as well as diet, metabolism and physiology.
You are young and I do so hope you can keep the beast at bay. Keep fighting this relentless enemy.
I've posted a brief history of my PD very recently on "introductions and personal stories" so I won't bore you with my details.