4Madapor AND Mucuna Prurines?

Madapor AND Mucuna Prurines?
Hi everyone!
Since I was diagnosed in March 2018 I have been taking controlled release 25/100 Madapor, three times a day, as advised by my neurologist, which seems to help with my tremors but doesn’t touch my stiff and aching legs. During the first few months I extensively investigated naturapathic treatments, including Velvet Bean (Macuna Prurines) - which I’ve been taking alongside the Madapor. From what I have read, macuna has much going for it. There’s a lot of published research substantiating this claim but I would especially recommend reading Dr. Rafael Gonzalez’s excellent book ‘Mucuna verses Parkinson - Treatment with Natural Levodopa’. It contains over 100 references to relevant research sources. I have been adding mucuna to my daily meds for about nine months now and feal confident it’s helping. Has anyone else tried this approach, and if so, did it help? Additionally, my naturapathic investigations suggest a number of supplements that support the remaining dopamine producing neurons as well as the importance of helping mitochondria produce ATP (energy) more efficiently. This being especially relevant to people with Parkinson’s. It’s vitally important to protect existing neurons if the progression of the disease is to be achieved (check out nootropics and mitochondrial health to see how that might be relevant to slowing or even halting the progression of the condition). This whole topic deserves more attention, don’t you think.


After reading your post I read the book, as I have been keen to try the alternative route. I am still confused with dosages to take?
I have only just started meds Madopar 125 twice a day. I would like to reduce this with MP, but am a bit wary of where to get it from and how much to take?
Also in the book it mentions green tea containing Carbidopa so would this be a good thing to take along side MP?

Hello Steph22
I’m glad you found the book interesting. It really does present a good case for trying Mucuna Prurines. I can understand your uncertainty over doseages. Many Mucuna powders and capsules don’t specify the amount of L-Dopa per dose, however the one I’m using is sold as ‘Now Dopa Mucuna’ they state that their product delivers 15% L-Dopa (120mg per dose of two capsules). I get mine from Amazon but search the web and you will find a number of suppliers. You only appear to be on a low dose of Madapar so you may find that Mucuna is a good effective substitute for Madapor. I have tried gree tea but hate the taste so by brew-ups use good old Yorkshire tea!.
Hope that helps.

Thank you
Yes it does, I will try the now one

All the best

Hello, Borg3of21,

I hope you are keeping well.

I have started the Mp along side a reduced dose of Madopar 50/12.5,
It is early days but I am planning on increasing MP and removing Madopar.
I am interested in the other supplements you mention you are taking? I am also taking turmeric and cbd oil.
Many thanks

I was prescribed Madopa and took it for 6 months during which time II felt permanently queasy and also uneasy about my body’s distaste for the drug. I also distrust the drug for the fact that it has a long list of associated “side-effects” (I call them medically-induced alternative illnesses) that are waiting to pounce in the future.So I abandoned Madopa and settled instead for Mucuna in the form of Zandopa powder. I have had no adverse reactions to this and experimented with dosage until I found one that does the job - in my case currently 20gms of powder in a little water twice per day.
I have also adopted the Auto Immune Paleo Diet on advice from a nutritional therapist in order to address chronic problems with my digestive system. I have been on it for 16 weeks now and it has done wonders. No more rumblings,bloating,constipation or diarrhea! I feel very well, optimistic about the future and I now sleep very soundly.
I like the sound of ‘Now Dopa Mucuna’ and may move towards using it eventually instead of Zandopa. Weighing out the powder is a pain and effectively rules out taking vacations away from home; but it currently has the advantage of enabling me to fine-tune my dosage. This is important because I don’t want to smother my tremor symptoms. If I do that I can’'t tell whether my other actions (like the AIP diet) are working or not. I have no aspirations of finding a cure; but my aim, which is entirely feasible, is to stop the disease’s progression and generate my own dopamine supply by natural means. Right now, I think I am winning!
I absolutely agree with you about the lack of support/attention of Mucuna. It deserves a lot more attention than the UK authorities are giving it. But it is hardly surprising, is it? I don’t suppose the pharmaceutical industry wouldn’t make any profit out of it. John

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I love your expression “medically-induced alternative illnesses”. That so approprietly applies to so many conventional pharmaceutical ‘treatments’, in my opinion - especially the so-called ‘gold standard’ conventional Parkinson’s meds. My neurologist hadn’t heard of mucuna prurines, nor did he say anything regarding the benefit of taking any supplements. That I had to discover for myself. The medical profession doesn’t like it when you do this, but do it and see the bigger picture. For example; discover how PQQ (Pyrroloquinoline Quinone) improves mitochondrial efficiency and boosts energy levels. Learn the benefits of taking co-enzyme Q10, and check out what natural Astaxanthin can do to improve your overall health. There’s a dozen or so other supplements that can help ease the symptoms of Parkinson’s disease - but the medical profession seems unwilling or unable to offer any help or guideance on supplementation.

When it comes to buying mucuna prurines in powder form, I’ve discovered a UK based company (DetoxTrading) that supply a good organic mucuna prurines powder. I make up my own capsules from this powder which works well for me.

I too look to hold back the disease progression and for me that seems to be through careful supplementation. From the extensive reading I have done on the subject I even believe it’s possibe to reverse some or all of the symptoms, given time and the right supplements.

So, I say listen to the medical men but don’t be deterred from following your own path along the Parkinson’s road.

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Very interesting posts.
Can you tell me how long it took for the MP to help? Was it one to two weeks?
I have been taking for almost a week and wondering if I should increase the dose yet or wait a few more days to see if the dose is right for me

Many thanks

Hi Steph22
I would say that my tremor was lessoned within about an hour of first taking mucuna prurines. I now take one capsule of MP, three times a day (plus one Madapor 25/100 three times a day) which works very well at supressing my tremors but I have to say that neither MP nor Madapor has helped improve my weak and aching legs. I have tried increasing the dose but to no avail. I still think that MP has benefits and fewer side-effects than Madapor, so I’ll see how it works in the longer term.

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Hi Borg3of21

Thank you for your reply, I have ordered some powder from detox trading and plan to make capsules

They suggest 1/4 tsp a day which seems quite a high dose?
I’m hoping the MP will help to avoid increasing Madopar too soon.


Hi again Steph22
I think you are right in giving MP a go. It has many health benefits in addition to delivering L-dopa. Start on a low dose for about a week or so, then up the dose if you wish. I think the suggested dose of the MP powder from Detox Trading of a quarter of a tablespoonful should be fine. If you are making up your own capsules, that might equate to two or three ‘00’ sized capsules per dose. Alternatively you could just mix with a little water and gulp it down (it’s not too unpleasant).
From the reading I have done on MP, it seems its chief benefits stem from the very large mix of compounds present in MP, which effectively serve to avoid giving rise to side effects and any tendency to stop working, as can be the case with synthetic l-dopa. It can be taken alongside madapor, benildopa etc. So I would suggest you supplement any existing medication by adding in MP starting with a low dose at first then see how you go.
I hope it works well for you!


Thank you so much for your message. It is really helpful to hear your comments. I have read so much,that I think I am on overload. So I am going to start with a simple plan.
Thank you again for taking the time to reply

Hi Borg3of21
Thanks for the tip about mucuna being available from Detox Trading. I have just placed an order with them. Price is comparable with that obtained direct from India but timescale for delivery is superior (2 weeks from India!). It will be interesting to compare quality and effects. I also take co-Q20 but I note that research into its effects seems to be grinding to a halt. I don’t know the reason but I would guess its because there is no money in it for Big Pharma.
For dietary advice I have been an enthusiastic customer of EntireWellbeing.com. I have been following their Paleo diet now for 22 weeks and it has done wonders for my digestive system. I have stopped losing weight and feel much more positive about myself. The diet means hard work in the kitchen (no manufactured stuff - only fresh, natural and organic fruit veg, meat and fish in good quantities. No junk AT ALL. But the effect on digestive performance is amazing.
Another good tip I have been given is to take cold showers - as long as you can stand it! I use the plunge pool at my local gym or switch my home shower from hot to a final douching in cold water. It not only stimulates my system as a whole but my tremor goes to sleep until I warm up again. So it seems to work as a direct exercising agent for the neural system. Go on - try it!!!

I haven’t ever ordered mucuna from India but I think the UK supplier do supply a good product, that is to say it works for me.
Did you mean co-Q10? I haven’t heard of Q20.
As regards cold showers, I have read how it’s a vagus nerve stimulent. I find the sudden shock of cold water too much to handle (I must be something of a wimp). What I do find helpful is a pain relief pen fired a few times on or just below my navel. The device I use is called a ‘Pain Gone’ pen, which I obtained from an eBay supplier. It’s much less of a shock than a cold shower but is said to have a similiar effect. I’m also trying out low dose nicotine to reduce the most unpleasant symptoms for me which is weak and aching legs. It’s only day two of my experiment - one niquitin lozenge (1.5mg) twice a day, but I read that some PwP find nicotin helpful. I hope it works for me!

Hi Borg3of21
Yes I did mean co-Q10. Sorry.
It’s interesting how PD can have such a wide variety of different symptoms for different folks. It really brings home the message that each individual person has to find their own way of dealing with the disease. I like much of what you have described as your way of dealing with it. It closely resembles my own philosophy and practice but I think I will stick with my cold showers!

I agree with you that we all have to find what does and doesn’t work for us all individually. Progress is hard to judge from the mix of good days and bad days and the trying out of this or that therepy, supplement etc. I do believe it’s important to ‘know the enemy’, so I think it’s vital to do the research then formulate a plan of attack - and continuously revise it as one goes. Just following the advice of one’s neurologist, without question or investigation is hardly likely to bring any benefits. My neurologist hadn’t heard of mucuna, had nothing to say about Q10 or any other supplement, or how supporting and enhancing mitochondria health might help allieviate some symptoms. All he offered at my last visit was to up the benildopa from three a day to four a day, and come back in six months! No, that’s far too simplistic and short-sighted way of making any headway with this complex and personal condition.

Hi @Borg3of21,

I see there has been some conversation about the ‘Pain Gone’ pen which is great. However, I just wanted to chime in quickly, I can see that the item has been given medical device status, but I would advise you to seek advice from a clinician before purchasing a product such as this to ascertain its suitability to you.

Hope you find my 2 pence useful and if you have any questions, feel free to give us a quick call via our helpline on 0808 800 0303.

Best wishes,

Hi, I am glad to connect and hear about your experience with MP.

My mum is 83yo and diagnose with PD since 2011. Her dosage for sinmet had been increasing over time as that had been the conventional protocol by her neurologist. Studies had shown that increasing sinmet will have wear out effect and increased dyskinesia.

In the last 3 years, I had taken a similar path that you had taken ie conventional medication and MP.

We have experimented and in fact she is functionally well with the following replacement. Sinmet 250/50 can be replaced with MP 350mg LD and 50 mg 5-HTP (avail in capsule). Since MP metabolised in the stomach easier that sinemet and could reduce the dose of dopamine to the brain it is best to have it 30mins before or after meals. 5-HTP helps as we need to balance the three chemicals in the brain. A boast of dopamine without the other two going well will give her a nauseating feeling.

Hope this helps. I am still reading and researching and hope to learn more on how to care for my mum. Has others gone through the same journey?

Hi JohnnyW
Thanks for this. Could you help me here please? I guess that “MP” is Mucuna Pruriens but “5-HTP” and “350mg LD” are new to me. Please enlighten me.
Thanks JCPB

MP 350mg LD = Mucuna Pruriens at 350mg Levodopa.
5-HTP = 5-hydroxytryptophan. This supplement is a precursor to Serotonin for the brain.

The drug sinemet it is a combination of Levodopa and Carbidopa. Carbidopa only purpose is to make Levodopa palitable. If one takes only Levodopa (which was the case pre 1975, before sinemet was developed), patient will feel nauseous and often feel like vomiting. After 1975 sinemet was developed. This drug is named sinemet as “sin” in latin means “no”; “met” means “vomit”. It is no surprise that the drug mean “no vomit”. Carbidopa main purpose is to stop the nauseating feeling. But the long term side effect of carbidopa needs investigation. Interestingly since 1975 the increase of dyskinesia in PD had drastically increased. Some research suggest it is the effect of long term carbidopa as it reduces vitamin B6. People with deficient vit b6 have the same symptoms as PD.

5-htp makes increased levodopa palitable as it balances the serotonin level in the brain, and thus no nauseating feeling.

My mum also takes vit b6 supplement.

Hope this helps.