Entacapone


#1

Hi

My  PD nurse suggests I try Entacapone alongside sinemet. I would be interested to hear from anyone who has been prescribed this drug, the side effects and how long it takes for Entacapone to kick in.

 


Thanks

Powrie


#2

 

Hi


I take it alongside madopar to extend life and benefits of madopar, like most things PD it slowly may take a couple of weeks to kick in, i was only advised 1 in 10 cant tolerate it that may cause severe Diarrhea, but i wasn't one of those 1 in 10, the other side effect which if one was marrooned at the north pole or alaska one would be able too pee S.O.S in bright orange.


#3

Hi

I am on my 2nd week of taking 4 entacapne a day with my sinemet. Not working fully for me as yet. NO side effects.

hope you get on okay. xx


#4

Hi Sea Angler

Many thanks for your vivid description on the side effects of Entacapone.!!  I must be one of the unlucky ones as I am experiencing side effects i.e.  diarrhoea, nausea, sweats,very dry mouth and of course bright orange pee!  I have only been taking Entacapone for 4 days so I am hoping these horrible side effects will stop soon and I will start to feel some benefits.   Do you feel that Entacapone is working for you?

 


Powrie

 


#5

Hi Glasgow girl


Thanks for your reply.  I am experiencing side effects i.e. diarrhoea, nausea, very dry mouth, sweats and bright orange pee,  so I am one of the unlucky ones, but I have only been taking it for 4 days.  The dose I have been prescribed is 1 x tablet 200 mg.  I see you are taking  Entacapone  4 times per day - what strength of Entacapone do you take?  I'm not sure how long I can  put up  with all the side effects and not feel any benefits !  

I hope it starts working fully for you very soon.

 

Regards


Powrie

 

 


#6
Works for me no side affects just the bright tango pee , can give you a bit of dyskinesa until you sort your meds out

#7

I also have bright orange pee.This is not a side effect in my book, as does not upset me.i am on 4 200mg taken with my sinimet plus.

In another 2 weeks going up to 5 entacapone. Hopefully by then working fully.

 

 

 

 

 

 


#8

Hi Gus

Thanks for your reply. Glad it works for you. 

 

Powrie


#9

Hi Glasgow Girl


Thanks for your reply.  Hope Entacapone continues being beneficial to you.

Powrie


#10

 

Hi Powrie


if you are having those side effects especially diarrhea  I would check back with who ever prescribed the entacapone for further advice, im sure i remember another pill being announced that works similar too entacapone but is one daily dose i think Gus had a go with it Safinamide ??

 


#11

yes i did give safinamide ago ,i don't think i personally gave it a chance but its available ,,if you type it in it comes under a different name the chemist seem to know this name of brand better !


#12

Hi Sea Angler

Many thanks for your helpful advice.

Powrie

 

 


#13

Ive added entacapone 5 months now.I was taking 7 25/100 c/l and 1 50/200 sr c/lAfter adding 1 200 mg split early two doses I cut the sinemet down to 3.5 25/100 a day with better results then before.Since the beginning I added 1 exrra 100 mg comtan with 3 rd c/l

Sideeffects seem just gas sometimes .But less constipation.Overhaul Im happier I found it  .

I think people who try it start at no  more than a half pill  with their c/l I think even now taking 1 pill would be to much.

My myoclonus has pretty much gone away with changing from Actavis to Mylan Pharm c/l 25/100,

I am getting many reports now from others who get different results with our generic c/l.

Why I dont know but should be investigated by the FDA.


#14
Hi all I have been taking entacapone now for 18 months with my madopar. I found on a really good day I would get 6hrs out of mine. 200mg x 4 but as saud that was on a really good day very calm comfy and warm and relaxed. Bear with the side effects they can generally do settle. If not try stalevo. Good luck. BB xx

#15

Hi All

Didn't have much luck with Entacapone 200mg - side effects too much ! Have now stopped taking it.  There's one more question I would like help with and I'm sure you guys will try your best.  I am prescribed Sinemet 12.5mg/50 mg -  2 x 5  times a day  and 1 x 1 mg Rasagiline daily. Does anyone know if this is a high dose of Sinemet   or not?  I have been told by 2 professionals that this is a low dose of Sinemet but another professional has told me that it's a high dose of Sinemet.  I am confused!  I am not getting long enough between doses ,especially after first dose  in the morning.

 


Thanks All

Powrie


#16
The dosage is dependant on your body weight as we need fat reserves to distribute the drugs evenly around our system. For instance at dx I was 12.5 stone last month at my lightest myI weight was 8 stone due to the drugs I needed to take to control my symptoms my dose of madopar was 10 x 62.5 mg taken with an entacapone over 4 stints during course of the day and I was also on 3 other pd meds I was up to the max with what I can take. Madopar and Siminet same drug different name. To confirm you need to asked your Dr about this as a lot of people are not aware their weight is a factor when prescribing meds. Let me know how you get on I am now reducing my intake thanks to DBS surgery giving me my life back if you find you are at the hilt of your meds I implore you look at DBS With your eyes wide open for me it has been fantastic. BB xx

#17

thats great news bb.

                                    i was told there are no max dose for sinemet when  your symptoms get really bad interesting !


#18

Hi BB


Thanks for your information.  I had no idea that weight played a part in your medication!  At no time was this factor mentioned either by the Doctors or the PD nurse.  I see PD nurse in a few days and will be asking about this. As for DBS it frightens me even to think about it! I am really pleased it has worked out so well for you.  Will let you know how I get on with PD nurse.

Powrie


#19

Hi Gus

 

Thanks for reply.  Can I ask who told you there was no max dose of sinemet.  I am getting mixed messages from the professionals and don't know what to think

Powrie


#20

my parkinsons movement nurse for dbs as i brought the conversation up with her when my gp said i was at the max dose , & my dbs nurse said they have patients on 2000 mg of sinemet ,guide lines must be in place for gps .